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KMID : 0620920220540040358
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Experimental & Molecular Medicine
2022 Volume.54 No. 4 p.358 ~ p.369
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Hypothalamic control of energy expenditure and thermogenesis
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Tran Le Trung
Park So-Hee
Kim Seul-Ki
Lee Jin-Sun
Kim Ki-Woo
Kwon O-Bin
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Abstract
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Energy expenditure and energy intake need to be balanced to maintain proper energy homeostasis. Energy homeostasis is tightly regulated by the central nervous system, and the hypothalamus is the primary center for the regulation of energy balance. The hypothalamus exerts its effect through both humoral and neuronal mechanisms, and each hypothalamic area has a distinct role in the regulation of energy expenditure. Recent studies have advanced the understanding of the molecular regulation of energy expenditure and thermogenesis in the hypothalamus with targeted manipulation techniques of the mouse genome and neuronal function. In this review, we elucidate recent progress in understanding the mechanism of how the hypothalamus affects basal metabolism, modulates physical activity, and adapts to environmental temperature and food intake changes.
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KEYWORD
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Endocrine system and metabolic diseases, Molecular neuroscience
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